Description:
The Organix Comprehensive Profile offers a complete quantitative organic acids test, providing data on the body's cellular metabolic processes and the efficiency of metabolic functions.


Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, and intestinal microbial activity. The accumulation of specific organic acids detected in urine often signals a metabolic inhibition or blockage. The metabolic blockage may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or negative drug effect. Several of the analytes measured are markers of intestinal bacterial or yeast overgrowth. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. 


Of special interest to the Organix Comprehensive test are:
  • Vitamin and mineral insufficiencies
  • Amino acid insufficiencies like carnitine and N-acetyl cysteine (NAC)
  • Oxidative damage and antioxidant sufficiency markers
  • Indicators to assess detoxification sufficiency
  • The best functional markers of B-complex deficiency
  • Neurotransmitter metabolites to assess central nervous system (CNS)  function
  • Mitochondrial energy production assessment via citric acid cycle components
  • Methylation sufficiency status
  • Lipoic acid and CoQ10 sufficiency markers
  • Specific dysbiosis markers for bacterial and yeast overgrowth
Tests for:
Organic acid concentration and metabolic function


Symtpoms and conditions:
  • Fatigue
  • Sleep abnormalities
  • Mood changes
  • Blood sugar dysregulation
  • Weight gain
  • Nausea
  • Multiple chemical sensitivity
  • Bloating
  • Distention
  • Joint pain
  • Gas
  • Reflux
  • Autoimmune disorders
  • Dermatitis
  • Depression
  • Anxiety
  • Cancer
  • Inflammation
  • Headaches
  • Early aging


Analytes Measured:
Fatty acid metabolism: 
Adipate
Suberate
Ethylmalonate
 
Carbohydrate metabolism:
Pyruvate
L-Lactate
Beta-Hydroxybutyrate
 
Energy production (citric acid cycle): 
Citrate
cis-Aconitate
Isocitrate
Alpha-Ketoglutarate
Succinate
Fumarate
Malate
Hydroxymethylglutarate
 
B-complex vitamin markers:
Alpha-Ketoisovalerate
Alpha-Ketoisocaproate
Alpha-Keto-Beta-Methylvalerate
Xanthurenate-Beta-Hydroxyisovalerate
 
Methylation cofactor markers:
Methylmalonate
Formiminoglutamate
 
Neurotransmitter metabolism markers:
Vanilmandelate
Homvanillate
5-hydroxyindoleacetate
Kynurenate
Quinolinate
Picolinate
 
Oxidative damage and antioxidant markers:
p-Hydroxyphenyllactate
8-Hydroxy-2'-deoxyguanosine
 
Detoxification indicators:
2-Methylhippurate
Orotate
Glucarate
Alpha-Hydroxybutyrate
Pyroglutamate
Sulfate
 
Bacterial – general:
Benzoate
Hippurate
Phenylacetate
Phenylpropionate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
Indican
Tricarballylate
 
L.Acidophilus/bacteria:
D-Lactate
 
Clostridial species:
3,4 Dihydroxyphenylpropionate






Test type:
Nutritional and metabolic: Organic acids, metabolic functions, detoxification


Sample required:
Urine


Average processing time:
8-14 days
organix-comp_sr_santitized_1062.pdf
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