Description:
​One of the first products of its kind in the world, DNA Diet tests for 13 genes that impact metabolism and exercise. The genes comprising the DNA Diet test have associations with body weight and body mass index, and all meet stringent criteria for utility in genetic screening tests. We provide a detailed report with recommendations that include dietary changes and an exercise programme.
  
Genes involved in regulation of energy expenditure, appetite, and fat metabolism, all play an important role in weight regulation. In fact 40% to 80% of the variance in body weight is due to genetic factors. This helps to explain why not everyone becomes obese even though people may be exposed to similar environments. Genetics thus determines an individual’s susceptibility to obesity when exposed to an unfavourable environment. It also explores the way a person responds to diet and exercise.

The DNA Diet test panel is designed to assist health practitioners in effectively managing body weight, by guiding the development of diet and exercise programs based on genetic differences in nutrient metabolism and body fat regulation. While healthy nutrition may in certain cases result in weight loss, it depends on many factors. The DNA diet provides a tailor-made nutrition and exercise programme.


All genes meet the following stringent criteria for utility in genetic screening tests:

• Have proven biological function. Many of the genetic variations in the test panel produce a change in the amino acid structure of the protein and change the activity of the protein. Other variations in the panel affect transcription factors in DNA-based communications.
• Have a plausible biological role in weight management. For example, some of the gene variations produce a change in the amount of fat absorbed from a meal or alter carbohydrate metabolism.
• Have evidence from clinical studies, that individuals with different genotypes have a differential response to either certain diets or different levels of physical activity.

Tests for:
Genes that impact metabolism, insulin sensitivity, satiety and feeding behaviour.


Analytes measured:
Fat absorption and metabolism
Fatty acid binding protein (FABP2)
Peroxisome proliferator-activated receptor-gamma (PPARG)
Apolipoprotein A-II (APOA2)
Beta-2 Adrenergic Receptor (ADRB2)
APOA5


Fat metabolism, obesity and satiety
APOA2 


Insulin sensitivity, and regulation of metabolism, feeding behaviour and energy intake
MC4R
FTO
TCF7L2


Training response:
Beta-3 Adrenergic Receptor (ADBR3)


Circadian rhythms
CLOCK
Alpha-actinin 3 (ACTN3 )


Fat storage
PLIN


Inflammation
TNFA

EUR 179.00